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| THE TANTRAYUDHA OF SAI RAM, VOLUME 101
BY SWAMI TANTRASANGHA
Subject: The Concepts of Truthfulness, Helpfulness, and Environment I just felt the presence of selfishness in some of the intellectual As a teacher of Tantra, I feel it is wrong to abandon Scientific I think you would agree with what St. Peter said: "Serve God, not I assume you are aware that the Liberation of the Soul from the body, Perhaps this public perspective is more into the helping of others |
For those truly interested in the Liberation of people from
sufferring, even the possibility of the Liberation from the Four
Physical Sufferrings, which meditation cannot touch, don't you think
those sworn to this Liberation from Sufferring would be interested in
testing Urine Tantra, to see if it works, especially with the vast
array of scriptural evidence for such Tantra and the many documented
cases of cures from the practice of Urine Therapy? Jai Om. - Sw.
Tantrasangha
Jeffrey Brooks <jhanananda@yahoo.com> wrote:
As for supporting you in some of your dialog. I am
more than happy to do so, however you seem to be going
for radical theories, such as urine therapy, which
only makes you look like a wako, so I reserve support
for such theories, because I do not thing they are of
core importance.
KALIMAN THE ANTICHRIST IN THE HEARTS OF MANY
This man is marketing himself to be a great meditation
teacher, but he cares not for any Truth he can't sell, and he won't
acknowledge his own ignorance about Tantra. All my words were
useless, for this man has all he wants, spiritually, and has no
interest in providing others with what he has denied unto himself.
Why would anyone study under someone so ignorant as to think urine is
dirty and heterosexual Tantra is depraved? Oh, the lies they tell in
order to sell their lying, ignorant "services" to their cheated
dupes.
You will note that Rasa Tantra is unpopular with unprincipled
materialists. They can hardly comprehend why one would say something
which might impede their acquisition of money and social approval.
Their only thought is, "What will people think?" The Truth hardly
even gets considered. They told Moses not to tell the Truth about his
Jewish lineage, or he would lose the chance to be the next Pharaoh.
He told the Truth and became a slave. His integrity and devotion was
that strong.
Preachers say whatever it takes to fill the collection plate, but
Jesus gave a speech (below) which made five thousand turn away. It
was the sermon about, "You must eat my body and drink my blood, or
you have no part with me". A pity Jhanananda did not have such
integrity, for his selfishness caused us to separate from each other.
In this "dog eat dog" world of the cheaters and the cheated, anything
better is regarded with loathing as merely more difficult
competition. Why did they kill Jesus? He had a better product. The
betterment of mankind has nothing but negative importance to the
devil who feeds off human suffering. Sai Ram
Subject: Gospel of John, Chapter 6:
My Esteemed Jhanananda, Tantra Kaana does not abnegate meditation or
study of the Sutras (in Sanskrit, Suttas in Pali, Suras in Arabic).
Notice that Jesus chose to remain with an unpopular but True Doctrine
rather than change to a more popular but less true doctrine, in order
to "suck up" to the masses who, as Jesus said: "Maketh and loveth
a
lie". The point I am making is: Why don't you want to find out if
Shivambu Tantra works or not? There is nothing to lose and everything
to gain. Are we not sincerely in the "business" of Liberation from
as
much suffering as possible? I repeat my theory that Jesus speaks of
Physical Immortality, but, as the Old Testament states: "Those who
break the fast must die the death." And if the unruly mob doesn't
want Liberation, would it not be better to choose another
profession? - Sw. Tantrasangha
The following is John's account of what Jesus said and what happened
around him. And Jesus said:
Gospel of John, Chapter 6:
48 I am that bread of life.
49 Your fathers did eat manna in the wilderness, and are dead.
50 This is the bread which cometh down from heaven, that a man may
eat thereof, and not die.
51 I am the living bread which came down from heaven: if any man eat
of this bread, he shall live for ever: and the bread that I will give
is my flesh, which I will give for the life of the world.
52 The Jews therefore strove among themselves, saying, How can this
man give us his flesh to eat?
53 Then Jesus said unto them, Verily, verily, I say unto you, Except
ye eat the flesh of the Son of man, and drink his blood, ye have no
life in you.
54 Whoso eateth my flesh, and drinketh my blood, hath eternal life;
and I will raise him up at the last day.
55 For my flesh is meat indeed, and my blood is drink indeed.
56 He that eateth my flesh, and drinketh my blood, dwelleth in me,
and I in him.
57 As the living Father hath sent me, and I live by the Father: so he
that eateth me, even he shall live by me.
58 This is that bread which came down from heaven: not as your
fathers did eat manna, and are dead: he that eateth of this bread
shall live for ever.
59 These things said he in the synagogue, as he taught in Capernaum.
60 Many therefore of his disciples, when they had heard this, said,
This is an hard saying; who can hear it?
61 When Jesus knew in himself that his disciples murmured at it, he
said unto them, Doth this offend you?
62 What and if ye shall see the Son of man ascend up where he was
before?
63 It is the spirit that quickeneth; the flesh profiteth nothing: the
words that I speak unto you, they are spirit, and they are life.
64 But there are some of you that believe not. For Jesus knew from
the beginning who they were that believed not, and who should betray
him.
65 And he said, Therefore said I unto you, that no man can come unto
me, except it were given unto him of my Father.
66 From that time many of his disciples went back, and walked no more
with him.
67 Then said Jesus unto the twelve, Will ye also go away?
68 Then Simon Peter answered him, Lord, to whom shall we go? thou
hast the words of eternal life.
ANOTHER REJECTED APPEAL FOR INTEGRITY
Subject: Dr. Wilhelm Reich's "Emotional Plague"
As a scientist or a rational person, "theory" is
the only correct description of Rasa Tantra for anyone following
Scientific Method. I did not mean to imply that you should get
involved with it, but, for some reason, it was imperative to me that
you be interested in finding out if it works. I hope that sincerety
and insight in Dharma remain your best qualities. The Science of
Liberation should not be restricted to any religion or practice, but
should be confined only to the Directive of Liberation from
Suffering, by any and all means deemed fitting or practical. Thus,
Dharma would be non-sectarian, and the only "hole" into which it has
to fit would be Truth itself. As Madame Blavatsky said: "There is no
religion higher than Truth".
Have you not perceived that almost the entire lot is not rational
in regards to considering the many intellectual facets of this Holy
Science, of which only beings of intelligence and compassion are
capable? In short, I concur with Dr. Wilhelm Reich's theory that the
vast majority are afflicted with the "Emotional Plague", which wages
socio-economic warfare against those of the True, Objective and
Unbiased Enquiry into the question of what is true or false in the
quest for Liberation from the 8-Fold Suffering.
Do you not perceive the oft-prophesied murder-suicide in which the
insane destroy themselves and others in this mind stuff of "Tat Vam
Asi", the union of subject and object or inner and outer? They are
against Christ but for false preachers, and they are almost all "cut
out of the same oak". Can you perceive these things? Naivete is not a
good trait for teachers. Do you perceive the mass insanity which
destroys the logical enquiry into spiritual matters, while "covering
its tracks" with false religions? There is no "good ground" in
which
to "plant the seed" of Truth. The combination of ignorance and
insanity with "high-tech" intelligence, spells certain doom for a
world already threatened by many other such ominous portents. May God
have mercy on those who have no mercy for the Truth. Jai Om. - Sw.
Tantrasangha
THE HOLY ROMAN CATHOLIC ALCHEMISTS
ST. ALBERT THE GREAT (ALBERTUS MAGNUS) of the Dominican Order. Tutor
to St. Thomas Aquinas.
COMPOUND OF COMPOUNDS
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Compound of Compounds
Albertus Magnus
[ Translated from the French by Lynn Bacarella; Produced by R.A.M.S.
(Restorers of Alchemical Manuscripts Society), 1978 ]
Preface
I will not hide a science which was revealed to me by the grace of
God; I will not jealously guard it for myself alone, for fear of
drawing His curse. A science kept secret, a hidden treasure, what is
its use? The science I have learned without invention, I transmit to
you without regret. Envy disrupts everything, an envious man cannot
be just before God. All science, all knowledge comes from God; it is
a simple way of speaking to indicate that it comes from the Holy
Spirit. No one can say: Our Lord Jesus Christ without also
understanding: Son of God the Father, through the operation of the
Holy Spirit. In the same way, this science of truth cannot be
separated from Him who communicated it to me.
I have not been sent to all, but only to those who admire the Lord in
his works and whom God judges worthy. Only whosover has ears to hear
His divine communication receives the secrets which have been
transmitted to me by the grace of God, and these He never reveals to
those who are unworthy.
Nature must serve as the foundation and the mode of science: the Art
also works according to Nature as far as it can. It is necessary
then, that the Artist observe Nature and operate as she operates.
Chapter I
Of the Formation of the Metals Generally from the Sulphur and the
Mercury
It is observed that the essence of metals, insofar as we know, is to
be produced in a general manner from Sulphur and Mercury. The
differences alone of cooking and digestion results in a
diversification of the metallic nature. I personally observed that in
a single vessel, in the same vein, so to speak, nature had produced
many metals, along with some silver disseminated here and there. We
have clearly demonstrated in our treatise on minerals that the
generation of metals is circular, that is, one passes easily from one
to another following a circle, the cousin metals having similar
properties; it is because of this that silver changes more readily
into gold than any other metal.
Indeed, there is not much in changing the color and weight of silver,
this is easy, because a compact substance increases its weight quite
readily. And since it contains a yellowish-white Sulphur, its color
will also be easy to transform.
It is the same with other metals. The Sulphur is, so to speak, their
father and the Mercury, their mother.
Again, it is most true, if one says of it that in the union the
Sulphur represents the sperm of the father and that the Mercury acts
as a coagulated Menstruum in order to form the embryonic substance.
The sulfur alone cannot produce, just as the father alone cannot
produce.
In the same way that the male begets his proper substance, in mixture
with the menstrual blood, likewise, the Sulphur produces with the
mercury, but alone it produces nothing. By this comparison we make
note that the Alchemist will have to raise at the outset, the
specificity of the metal which has given him the Nature, then that he
proceeds as nature proceeded, with the mercury and the Sulphur
prepared and purified always following the example of Nature.
The Sulphur Contains Three Humid Principles ~
The first of these principles is especially elevated and volatile,
one finds it in the exterior parts of the Sulphur, for the same
reason, that of the great volatility of its elements, which ignite
easily and consume the bodies with which they come into contact.
The second principle is phlegmatic, otherwise called aqueous; it is
found in close association with the former. The third is radical,
fixed, adherent to the internal parts. That one alone is general, and
one cannot separate it from the others without destroying the whole
edifice. The first principle does not resist the fire; being
combustible, it consumes itself in the fire and calcines the
substance of the metal with which one heats it. Therefore, it is not
only useless, but detrimental besides, to the goal which we set
ourselves. The second principle does not make the bodies moist, it
does not produce, it cannot serve us at all. The third is radical, it
penetrates all the particles of the matter which are necessary to its
essential properties.
It is necessary to rid the Sulphur of the first two principles in
order that the subtility of the third force serve us in making a
perfect compound.
The fire is nothing other than the vapor of the Sulphur; the vapor of
the Sulphur, well purified and sublimed white and rendered very
compact. Also the Alchemists are accustomed to skillfully raising the
two superfluous principles in the Sulphur by way of acid baths, such
as vinegar of lemons, sour milk, the milk of goats, the urine of
infants, etc. They purify it by lixiviation, digestion and
sublimation. It is necessary, finally, to rectify it by reduction in
a manner so as not to have more than one pure substance containing
the active, perfectible brother-force of the metal. Behold! We are
oin possession of one part of our work.
Of the Nature of the Mercury ~
The Mercury contains two superfluous substances, the earth and the
water. The earthy substance has something of the Sulphur. The fire
reddens it. The aqueous substance has superfluous humidity. One
easily rids the mercury of its watery and earthy impurities by
sublimation and very acid baths. Nature separates it into the dry
state of the Sulphur and robs it of its earth by the heat of the Sun
and the Stars.
It obtains thus a pure Mercury, completely free of its earthy
substance, containing no more foreign particles. It unites it then
with a pure Sulphur and produces in the end the pure and perfect
metals in the heart of the earth. If the two principles are impure,
the metals are imperfect. This is why one finds different metals in
the mines, which possess of the purification and of the digestion
according to their rudiments. This is dependent on the cooking.
Of the Arsenick ~
The Arsenick is of the same nature as the Sulphur; both tint to red
and to white. But there is more humidity in the Arsenick, and it
sublimes less rapidly over the fire than the Sulphur.
One knows how well Sulphur sublimes quickly and how it consumes all
the bodies, except God. The Arsenick can unite its dry principle with
that of the Sulphur, they temper each other, and once united, one
separates them only with difficulty, their tincture is toned down by
this union.
"The Arsenick", says Geber, "contains much of the Mercury; it
can
also be prepared like it". Know that the Spirit hidden in the
Sulphur, the Arsenick and the animal oil, is named by the
philosophers The White Elixir. It is unique, miscible with the
volatile substance, from this one we extract the red Elixir; it
unites with the melted metals, thus as we have experimented with it,
it purifies them. Not only because of the aforementioned properties,
but also because there is one common proportion between its elements.
The metals differ between themselves according to the purity or
impurity of the first matter, so to speak, of the Sulphur and of the
Mercury, and also according to the degree of the fire which produced
them.
According to philosophy, the Elixir also is called Medicine, because
one assimilates the body of metals in the body of animals. Also we
say that there is a hidden Spirit in the Sulphur, the Arsenick and
the oil extract of the animal substances. It is that spirit for which
we search, with whose aid we will tint all the imperfect bodies to
perfection. This Spirit is called Water and mercury by the
Philosophers. "The mercury", says Geber, "is a medicine composed
of
the dry and the humid, the humid and the dry". You understand the
succession of operations: extract the earth from the fire, the air
from the earth, the water from the air, since the water can resist
the fire. It is necessary to mark well these teachings, they are
Universal Secrets.
None of the principles which enter into the Work have strength by
themselves; for they are linked in the metals, they cannot be
perfected, they are not very fixed. Each lacks two substances, one
miscible with the metals in fusion, the other fixed which enables it
to coagulate and fix. Also Rhases said: "There are four substances
which change in season: each one of these is composed of the four
elements and takes the name of the dominant element. Their marvelous
essence was fixed in one body, and, with this last, one can nourish
the other bodies. This essence is composed of water and of air,
combined in such a way that the heat liquefies them. Here it is: a
marvelous secret. The minerals employed in Alchemy must, in order to
serve us, have an action upon the melted bodies. The stones we use
are four in number, two tint to white, the two others to red. Also:
the white, the red, the Sulphur, the Arsenick and Saturn have only
that one same body! But in this single body, what obscurities! And at
first it is without action upon the perfect metals".
"In the imperfect bodies, there is an acid water, bitter, harsh,
necessary to our Art. As it dissolves and mortifies the bodies, it
them revives them and recomposes them..." (ABRIDGED HERE - ED.)
UROTHERAPY FOR PATIENTS WITH CANCER
Joseph Eldor, MD
Theoretical Medicine Institute
P.O.Box 12142, Jerusalem, 91120,Israel
Abstract
Cancer cells release various antigens, some of which appear
in the urine. Oral auto-urotherapy is suggested as a new
treatment modality for cancer patients. It will provide the
intestinal lymphatic system the many tumor antigens against
which antibodies may be produced. These antibodies may be
transpierced through the blood stream and attack the tumor
and its cells.
The philosophy of cancer
Microbes were known long before the germ theory of disease
was invented. It was not the discovery of germs that
revolutinized medicine, but the invention of a philosophy of
medical explanation that permitted germs to be causative
agents of disease (1).
Burnet and Thomas (2) postulated that specific cell
mediated immunity may have evolved in vertebrates
specially for defense against the "enemy within" rather than
against infecting microorganisms and parasites. Most human
cancers appear to lack truly tumor-specific antigens. The
same neoplastic cell can express several different tumor
antigens. For example, relatively cross-reacting
tumor-specific transplantation antigens have been
demonstrated in many chemically induced tumors (3).
Tumor-associated differentiation antigens are shared by
neoplastic and embryonic cells (4). The extent to which
human patients react immunologically against their cancers
has been a subject of much controversy (5).
Paul Ehrlich, in 1909, said:"I am convinced that during
development and growth malignant cells arise extensively
frequently but that in the majority of people they remain
latent due to the protective action of the host. I am also
convinced that this natural immunity is not due to the
presence of antimicrobial bodies but is determined purely by
cellular factors. These may be weakened in the older age
groups in which cancer is more prevalent" (6).
Tumor antigens in urine
Human melanoma cells express membrane antigens distinct from
those of the normal ectodermal counterparts (7).
Urinary-tumor-associated antigen (U-TAA) is one such
antigen. This high-molecular weight glycoprotein was first
described when melanoma urine was found to react with
autologous antibody (8). The antigen has since been detected
in the urine of 68% of melanoma patients. In addition, high
levels of U-TAA are found to correlate positively with
disease occurrence in surgically treated patients (9).
Prostatic specific antigen (PSA) has become an important
laboratory test in the management of prostate cancer. PSA
levels can be as readily obtained from voided urine as from
serum samples (10).
Quantitative urinary immunocytology with monoclonal antibody
(mab) 486p 3/12 proved to be valuable for diagnostic use in
bladder-cancer patients` urine, especially in the followup
of patients with superficial bladder carcinoma (11).
Quantitative urinary immunocytology is a general tool to
test the diagnostic usefulness of mabs, assuming that normal
and malignant cells differ in their quantitative expression
of a given antigen. Selective criteria for selecting mabs
for diagnostic approaches should ask not for tumor
specificity, but for different quantitative expression of
antigen in the tissues or cells in question.
Gastric juice oncofetal antigen determination, due to direct
shedding of antigens into the fluid around tumor tissues,
appears to accurately indicate the presence and degree of
gastric mucosal damage and to be to a slight extent
influenced by unrelated factors (12). Patients` age, for
example, modifies CEA serum levels (13). A monoclonal
antibody (mab) against a human colorectal adenocarcinoma
cell line has been raised (14), which reacts with
sialosylfucosyllactoteraose (15) corresponding to the
sialylated blood group antigen Lewis (a). The antigen
defined by this antibody, CA50, is elevated in the serum of
many patients with gastrointestinal tumors (16), with a
sensitivity for gastric cancer ranging from 20 (17) to 65%
(18). CA50 (a tumor-associated gangliosidic antigen) levels
have been determined by an RIA test in serum, gastric juice
and urine of patients undergoing upper gastrointestinal
tract endoscopy. Sensitivity and specificity were
respectively 23% and 89% for CA50 determination in urines
(19).
Soluble forms of membrane proteins such as cytokine
receptors or cellular adhesion molecules (CD14, TNF
receptor, CD25, IL-6 receptor, IFN-ç-receptor and CD54) have
been detected in human body fluids. They may have important
functions in immune regulation by blocking receptor/ligand
interactions. The human adhesion receptor CD58 (LFA-3) is
expressed on most cell types. A soluble form of CD58 (sCD58)
was purified from human urine and partially purified from
supernatant of the Hodgkin-derived cell line L428 (20).
Urinary organ-specific neoantigen from colorectal cancer
patients has been used to make a monoclonal antibody, BAC
18.1 (21). Organ-specific neoantigen originates in the colon
and is excreted into the urine, so the BAC 18.1 binding
levels in the urine may be a diagnostic aid for colorectal
cancer.
The polyamines spermidine, spermine and their diamine
precursor putrescine are ubiquitous constituents of
mammalian cells that are fundamentally involved in normal,
malignant and induced proliferative states. The polyamines
and ornithine decarboxylase (ODC), the rate-limiting enzyme
of the polyamine metabolism, were found to play an important
role in tumor promotion (22). The suggestion that polyamines
play an important role in colorectal cancer was confirmed by
studies that found elevated polyamine concentrations in
blood or urine (23) of patients with colon carcinoma.
Sensitivity of urinary polyamines for colon cancer were
highest for total spermidine (92.1%), acetylated putrescine
(84.5%), total putrescine (84.0%), N1-acetylspermidine
(79.3%) and N8-acetylspermidine (78.6%), but in all these
cases specificity was lower than 65% (24). In patients with
successful curative surgical treatment all preoperatively
elevated urinary polyamine concentrations markedly decreased
and returned to normal, whereas they were elevated and
increased further in patients with proven relapse of the
tumor and/or metastases in different organs (24).
The function of the CD44 gene is severely damaged, beginning
with the very early pre-invasive stages of tumor
development. This can be used as a means of tumor detection
and diagnosis both on solid tissue specimens (25) and on
exfoliated cells in clinically obtained excreta and body
fluids (26). Urine cell lysates obtained from patients with
bladder cancer can be discriminated from normal urine
lysates (27) using Western blotting with a monoclonal
antibody against the standard form of the CD44 protein.
Immunotherapy
Zbar and Tanaka (28) first reported on animal immunotherapy
based on the principle that tumor growth is inhibited at
sites of delayed hypersensitivity reactions provoked by
antigens unrelated to the tumor.They injected living
Mycobacterium bovis (strain BCG) into established
intradermal tumors and caused tumor regression and prevented
the development of metastases. For optimum therapeutic
effect contact between BCG and tumor cells was necessary.
The ability of tumor immune lymphocytes to localize
specifically to tumor offers a possibility for therapy which
has been utilized over the past several years (29).
The rejection of murine tumors expressing tumor-specific
transplantation antigens has been shown to be mediated
primarily by immune cells (30). Some 6 to 7% of transplant
recipients may develop cancer as a consequence of iatrogenic
immunosuppression (31).
Studies on the ability of patient lymphocytes to lyse tumor
cells in short term (2-8 hr) isotope release assays have
shown that lymphocytes from cancer patients can generally
destroy only tumor cells from the same patient (32-34),
unless the effector cells are not cytolytic T cells but, for
example, Natural Killer cells or Lymphokine Activated Killer
cells, in which case neoplastic cells representing many
different types are sensitive.
Immunotherapy is believed to be capable of eliminating only
relatively small amounts of neoplastic cells and, therefore,
the failure to induce a regression in patients with
excessive tumor burden is not unexpected (35,36). One
approach of immunotherapy is to "xenogenize" tumor cells by
virus infection. Another is to culture tumor infiltrating
lymphocytes with interleukin-2 and reinoculate them into the
host with cytokines (37). The introduction of recombinant
vectors expressing cytokine genes into tumor infiltrating
lymphocyte cells (38) or into the tumor cells themselves
(39) may enhance the migration of effector immune cells into
the tumor with consequent immunomediated control. The
considerable heterogeneity in the expression of tumor
associated differentiation antigens by cells within the same
tumor constitutes a problem for any immunotherapy, since it
facilitates the escape of antigen-negative tumor variants.
An alternative approach toward increasing the immune
response to tumor-associated differentiation antigens is to
treat the host to be immunized so as to abolish a
"suppressor" response. Such treatment can be provided in the
form of sublethal whole body x-irradiation (40), injection
of a drug such as cyclophosphamide (41), or by the
administration of certain anti-idiotypic antibodies (42).
Anergy is defined as a state of T lymphocyte
unresponsiveness characterized by absence of
proliferation,IL-2 production and diminished expression of
IL-2R (43,44). Most available data support suppression as a
mechanism of oral tolerance (45,46). Immunological
suppression is classically demonstrated by the suppression
of antigen-specific immune responses by T lymphocytes
(47,48).
Autoantigens
Oral administration of S-antigen (S-Ag), a retinal
autoantigen that induces experimental autoimmune uveitis,
prevented or markedly diminished the clinical appearance of
S-Ag-induced disease as measured by ocular inflammation
(49,50).
Gut associated lymphoid tissue has the capacity to generate
potent immune responses on one hand, and to induce
peripheral tolerance to external antigens on the other
(51-53). Both processes require antigen stimulation (53),
involve cytokine production (51) and might occur at the same
time - the first leading to potent local and systemic immune
responses, while the latter leads to systemic
antigen-specific nonresponsiveness (54). The generation of
acquired immune responses in the small intestine is believed
to occur in Peyer`s patches (51,55).
Orally fed protein antigens are found in the blood within 1
hr of feeding (56). Peripheral tolerance is not induced
locally, but rather is induced systemically upon transfer of
intact antigen, or its peptides, into the circulation
(57-59).Oral tolerance may be induced by a single feeding of
a protein antigen (60,61) or by several intermittent
feedings (46,62). In order to test whether feeding on
autoantigen could suppress an experimental autoimmune
disease, the Lewis rat model of experimental autoimmune
encephalomyelitis was studied (63). With increasing dosages
of GP-MBP, the incidence and severity of disease was
suppressed, as well as proliferative responses of lymph node
cells to MBP. Antibody responses to MBP were decreased but
not as dramatically as proliferative responses. Thus it
appears that oral tolerance to MBP, as to other non-self
antigens (45), preferentially suppress cellular immune
responses. It appears that homologous MBP is a more potent
oral tolerogen for experimental autoimmune encephalomyelitis
than heterologous MBP (64).
Tumor cells may escape immune recognition in immunocompetent
hosts by clonal evolution.Attention could be directed to
activate the resident immune effectors to break the anergy
or tolerance.
Urotherapy
Subcutaneous urine injections was practiced in 1912 by
Duncan (65) from New York under the name of auto-pyotherapy
for urinary infections, and in 1919 by Wildbolz (65) from
Bern for diagnostic purposes. Cimino (66) from Palermo
reported in 1927 on the use of auto uro-therapy for urinary
infections. Rabinowitch (67) in 1931 described this
auto-urine therapy for gonarthritis. Jausion et al. (68)
used this kind of therapy in 1933 for desensitization and
endocrinological problems. They treated with auto urotherapy
injections patients who suffered from migraine, pruritus,
asthma, urticaria, eczema, psoriasis, etc. Day (69)in 1936
treated patients with acute and subacute glomerulonephritis
by injection of an autogenous urinary extract. Sandweiss,
Saltzstein and Farbman (70) reported in 1938 that an extract
from urine of pregnant women has a prophylactic and
therapeutic effect on experimental ulcers in dogs. Shortly
thereafter the same group noted that an extract from urine
of normal women has a similar beneficial effect (71).
In 1926 Seiffert first described the construction of ileal
loop conduits for urinary diversion (72). Bricker in the
1950s popularized the use of the ileal loop as a means of
supravesical urinary diversion following exenteration for
pelvic malignancy in adults (73). Ureterosigmoidostomy as a
means of urinary diversion was used widely from 1920 to
1955. It was this type of implant which Hammer first
reported in 1929 associated with tumor (74).
Peyer`s patches are immunocompetent lymphoid organs which
participate in intestinal immune responses (75). Epithelial
cells within the crypts of the small bowel are one of the
fastest dividing cells in the body and yet they show one of
the lowest rate of malignant transformation (76). Stem cells
in the mucosa of the small bowel can divide every 8 to 12
hours (77). Tapper and Folkman (78) demonstrated that
exposure of intestinal segments to urine causes marked
lymphoid depletion in the segments. These studies give
additional support to the idea that a lymphocyte suppressive
factor exist in urine (79). The continued presence of urine
bathing the intestinal mucosa appears to locally inhibit
regeneration of the Peyer`s patches.
Starkey et al. (80) detected in human urine a material that
is biologically and immunologically similar to epidermal
growth factor that causes proliferation and keratinization
of epidermal tissues.
The increased susceptibility of the colon to cancer
associated with the existence of an implanted ureter has
been theorized to relate to 3 factore: 1. The role of the
urine in the colon (81,82). 2. The mechanical effect of the
fecal stream on the stoma (83). 3. The age of the
anastomosis (84). Adenocarcinoma of the colon mucosa is a
recognized complication of ureterosigmoidostomy. The tumor,
which develops adjacent to the junction of the ureter with
the bowel, occurs 500 times as often as in the population at
large and, in children so operated , 7,000 times as often as
in all persons under age 25. The latency period is 5 to 50
years (81,85-87).
It is common knowledge that malignant tumors may disappear
spontaneously although very infrequently (88-90). Usually it
is accepted that this could be due at least partly to an
immunological reaction (91,92). Renal adenocarcinoma is one
of the cancer types in which such spontaneous regressions
have been described most frequently (88,90).
Urinary extracts from patients with aplastic anemia (93) and
idiopathic thrombocytopenic purpura (94) are capable of
stimulating megakaryocyte colony growth in culture, and when
injected into rats could also induce thrombocytosis in
peripheral blood and megakaryocytosis in the spleens of
these animals. Stanley et al. (95) demonstrated that rabbits
immunized with human urine concentrates from leukemic
patients developed antibody which neutralized the mouse bone
marrow colony stimulating factor in human urine and human
serum.
Preconclusion
Henry Sigerist said, more than 50 years ago:"I personally
have the feeling that the problem of cancer is not merely a
biological and laboratory problem, but it belongs to a
certain extent to the realm of philosophy... All experiments
require certain philosophical preparation. And I have the
feeling that in the case of cancer many experiments were
undertaken without the necessary philosophical background,
and therefore proved useless" (96).
Conclusion
Urotherapy is suggested as a new kind of immunotherapy for
cancer patients. Unlike the clonal immunotherapy the urine
of the cancer patients contain the many tumor antigens which
constitute the tumor. Oral auto-urotherapy will provide the
intestinal lymphatic system the tumor antigens against which
they may produce antibodies due to non-self recognition.
These antibodies may be transpierced through the blood
stream and attack the tumor and its cells.
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